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FIELD OF EXPERTISE
- Pancreatic Cancer
- Liquid Biopsies
- Circulating Tumor Cells
- Circulating Tumor DNA
PROJECTS
Background
With its rising incidence and poor prognosis, pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), is becoming a worldwide oncological problem. Currently, surgical removal of the PDAC offers the only chance for a cure. After neo-adjuvant therapy, a surgeon must evaluate whether borderline resectable (BR) and locally advanced pancreatic ductal adenocarcinoma (LAPDA) patients are eligible for/benefit from surgery. However, surgical resectability is often difficult to predict as spatial changes are unreliable on CT scans and the tumor marker (CA 19-9) is not specific enough. Therefore, there is a need for new, non-invasive diagnostic techniques that can better predict surgical resectability in PDAC patients.
Aim
The general aim of this study is to evaluate if a combination of clinical data and genetic profiling of liquid biopsies can successfully predict surgical resection in pancreatic cancer patients with BR or LAPDA. This would avoid unnecessary open abdomens, consequently improving the quality of life and make treatment more proficient.
Strategy
This project will investigate:
- the evolution of the number of circulating tumor cells (CTCs) in blood samples from patients and subsequently phenotype the CTCs using genetic and proteomic approaches
- driver mutations and epigenetic changes in cell free DNA
- proteomic evaluation of extracellular vesicles (EVs) and tissue leakage proteins (TLPs)
With its rising incidence and poor prognosis, pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), is becoming a worldwide oncological problem. Currently, surgical removal of the PDAC offers the only chance for a cure. After neo-adjuvant therapy, a surgeon must evaluate whether borderline resectable (BR) and locally advanced pancreatic ductal adenocarcinoma (LAPDA) patients are eligible for/benefit from surgery. However, surgical resectability is often difficult to predict as spatial changes are unreliable on CT scans and the tumor marker (CA 19-9) is not specific enough. Therefore, there is a need for new, non-invasive diagnostic techniques that can better predict surgical resectability in PDAC patients.
Aim
The general aim of this study is to evaluate if a combination of clinical data and genetic profiling of liquid biopsies can successfully predict surgical resection in pancreatic cancer patients with BR or LAPDA. This would avoid unnecessary open abdomens, consequently improving the quality of life and make treatment more proficient.
Strategy
This project will investigate:
- the evolution of the number of circulating tumor cells (CTCs) in blood samples from patients and subsequently phenotype the CTCs using genetic and proteomic approaches
- driver mutations and epigenetic changes in cell free DNA
- proteomic evaluation of extracellular vesicles (EVs) and tissue leakage proteins (TLPs)
DEGREES
- Master of Bioscience Engineering - Cell and Gene Biotechnology (Ghent University, 2021)
- Bachelor of Bioscience Engineering (Ghent University, 2019)